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Dr. Kheireddine El-Boubbou

Associate Professor

Chemistry
17437506
S41-1026
khboubbou@uob.edu.bh

Areas of Expertise

Organic Chemistry, Nanoscience, Functional Nanomaterials

Education

  • Ph.D. Chemistry, Michigan State University (MSU), USA
  • M.Sc. Chemistry, American University of Beirut (AUB), Lebanon
  • B.Sc. & Teaching Diploma Chemistry (with honor), Lebanese University

Biography

Dr. El-Boubbou received his M.Sc. in Chemistry from American University of Beirut in 2005, and Ph.D. from Michigan State University (USA) in 2010. Thereafter, he worked as a postdoctoral researcher at the University of Vermont (USA). In 2013, he joined KSAU-HS as an Assistant Professor of Chemistry, and was promoted to Associate Professor in 2017. Dr. El-Boubbou authored many peer-reviewed research papers published in high-impact journals with ~ 2500 citations, several book chapters, and hold two patents. He was elected as the recipient of several awards including pre-doctoral AHA fellowship and AICCS Young Investigator Award, to name few. He also received several best paper and presentation awards in national and international conferences. Dr. El-Boubbou serves as member, referee, and reviewer for many international renowned scientific journals. His research focuses on the design of functional magnetic nanomaterials utilized for various biological, catalysis, sensing, bioremediation, and biomedical applications (i.e. detection, imaging, drug delivery, and theranostics).

Achievements

  • 2021 Arab Fund Fellowship Award, funded by Arab Fund for Economic and Social Development, Kuwait.
  • 2020 President’s Award for Excellence “Outstanding Faculty Researcher Award, KSAU-HS, Riyadh, Saudi Arabia.
  • 2017 Best Paper Award, 19th International Conference on Nano and Materials Science (ICNMS), Paris, France.
  • 2010 AICCS Young Investigator Award, Alberta Ingenuity Centre for Carbohydrate Science, Banff, Alberta, Canada.
  • 2009 Best Oral Presentation Award, 5th Midwest Carbohydrate & Glycobiology Symposium, University of Cincinnati,USA.
  • 2007 Best Oral Presentation Award, 3rd Midwest Carbohydrate & Glycobiology Symposium, Ohio State University, USA.
  • 2007 American Heart Association Pre-doctoral Fellowship Award, MSU, Michigan, USA.
  • 2006 First Year Outstanding Graduate Student, University of Toledo, Ohio, USA.
  • 2003 Honor List, B.Sc. in chemistry, Beirut, Lebanon.

Affiliations

Department of Chemistry, College of Science, University of Bahrain, Sakhir 32038, Bahrain.

Grants & Contracts Awarded

  • Arab Fund Award, Principal Investigator (PI), 2021. Hybrid Gold/Silver Iron-based Magnetic Nanoprobes for Multimodal Imaging and Photothermal Therapy.
  • PI Advances in biomedical imaging and theranostics using magnetic multifunctional nanoprobes. Project Number: RC13/204/R, KAIMRC, 2017.
  • Co-PI Developing a Nanoparticle-based detection method for MERS-CoV. Project Numbers: RC15/143/R and RC17/106/R, KAIMRC, 2018.
  • Co-PI Delivery of Plasmid DNA Incorporated Fluorescent Magnetic Nanoparticles into Isolated Single Cells: A Novel Method of Single Cell Transfection. Project Number: RC16/096/R, KAIMRC, 2018.
  • Co-PI Targeting viruses with multifunctional nanoparticles: A novel therapeutic and diagnostic approach. Project Number: RC19/121/R, KAIMRC, 2019.

Publications & Presentations

Selected Publications
  1. El-Boubbou, K.; Ximendes, E.; Teran, F. J.; Marin, R.; Artiga, A.; Ortgies, D. H.; Jaque, D. “PEGylated Opto-Magnetic Gold and Silver Sulfide Iron Oxide Nanoprobes for Synergistic Photothermal Therapy” ACS Appl. Nano Mater. 2024, 7, 12, 13959–13972. https://doi.org/10.1021/acsanm.4c02889
  2. Samman, N.; El-Boubbou, K.; Al-Muhalhil, K.; Ali, R.; Alaskar, A.; Alharbi, N.K.; Nehdi, A. “MICaFVi: A Novel Magnetic Immuno-Capture Flow Virometry Nano-Based Diagnostic Tool for Detection of Coronaviruses” Biosensors 2023, 13, 553. https://doi.org/10.3390/bios13050553
  3. Lemine, O. M.; AlGessair, S.; Madkhali, N.; Al-Najar, B.; El-Boubbou, K. “Assessing the Heat Generation and Self-Heating Mechanism of Superparamagnetic Fe3O4 Nanoparticles for Magnetic Hyperthermia Application: The Effects of Concentration, Frequency, and Magnetic Field” Nanomaterials 2023, 13(3), 453. https://doi.org/10.3390/nano13030453
  4. El-Boubbou, K.; Lemine, O. M.; Jaque, D. “Synthesis of novel hybrid mesoporous gold iron oxide nanoconstructs for enhanced catalytic reduction and remediation of toxic organic pollutants” RSC Adv. 2022, 12, 35989. https://doi.org/10.1039/d2ra05990h
  5. El-Boubbou, K.; Lemine, O. M.; Ali, R.; Huwaizi, S.; Al-Humaid, S.; AlKushi, A. “Evaluating Magnetic and Thermal Effects of Various Polymerylated Magnetic Iron Oxide Nanoparticles for Combined Chemo-Hyperthermia” New J. Chem. 2022, 46, 5489. https://doi.org/10.1039/D1NJ05791J
  6. Lemine, O. M.; Madkhali, N.; Alshammari, M.; Algessair, S.; Gismelseed, A.; El Mir, L.; Hjiri, M.; Yousif, A.; El-Boubbou, K. “Maghemite (ɣ-Fe2O3) and ɣ-Fe2O3-TiO2 Nanoparticles for Magnetic Hyperthermia Applications: Synthesis, Characterization and Heating Efficiency” Materials 2021, 14, 5691.
  7. El-Boubbou, K.; Ali, R.; Al-Zahrani, H.; Trivilegio, T.; Alanazi, A. H.; Khan, A. L.; Boudjelal, M.; AlKushi, A. “Preparation of iron oxide mesoporous magnetic microparticles as novel multidrug carriers for synergistic anticancer therapy and deep tumor penetration” Scientific Reports 2019, 9 (1), 9481.
  8. El-Boubbou, K. “Magnetic iron oxide nanoparticles as drug carriers: preparation, drug conjugation, and delivery” Nanomedicine (Lond.) 2018, 13(8), 929-952.
  9. El-Boubbou, K. “Magnetic iron oxide nanoparticles as drug carriers: clinical relevance” Nanomedicine (Lond.) 2018, 13(8), 953-971.
  10. El-Boubbou, K.; Azar, D.; Bekdash, A.; Abi-Habib, R. J. “Doxironide Magnetic Nanoparticles for Selective Drug Delivery to Human Acute Myeloid Leukemia” J. Biomed. Nanotechnol. 2017, 13, 500-512.
  11. El-Boubbou, K.; Rizwan, A.; Bahhari, H. M.; Al-Saad, K. O.; Boudjelal, M.; Kushi, A. “Magnetic fluorescent nanoformulation for intracellular drug delivery to human breast cancer, primary tumors, and tumor biopsies: Beyond targeting expectations” Bioconjugate Chem. 2016, 27, 1471-1483.
  12. El-Boubbou, K.; Zhu, D. C.; Vasileiou, C.; Borhan; B.; Prosperi, D.; Li, W.; Huang, X. “Magnetic Glyconanoparticles: A tool to detect, differentiate and unlock the glyco-codes of cancer via magnetic resonance imaging” J. Am. Chem. Soc. 2010, 132, 4490-4499.
  13. El-Boubbou, K.; Gruden, C.; Huang, X. “Magnetic Glyco-nanoparticles: A unique tool for rapid pathogen detection, decontamination and strain differentiation” J. Am. Chem. Soc. 2007, 129, 13392-13393. This publication was highlighted in the news: http://www.physorg.com/news114696140.html http://www.sciencedaily.com/releases/2007/11/071119110910.htm
PATENTS
  1. El-Boubbou, K., Ali, R., and AlKushi, A. “Iron Oxide Mesoporous Microparticle Drug Carrier” US Patent 2021, Patent no. US2021/0393798A1. https://patents.google.com/patent/US20210393798A1/en
  2. El-Boubbou, K. “Acid-stabilized iron-based metal oxide colloidal nanoparticles, and methods thereof” US Patent 2020, Patent Granted, US20170110228A1. https://patents.google.com/patent/US20170110228A1/en

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Dr. Kheireddine El-Boubbou

Associate Professor

Chemistry
17437506
S41-1026
khboubbou@uob.edu.bh

Areas of Expertise

Organic Chemistry, Nanoscience, Functional Nanomaterials

Education

  • Ph.D. Chemistry, Michigan State University (MSU), USA
  • M.Sc. Chemistry, American University of Beirut (AUB), Lebanon
  • B.Sc. & Teaching Diploma Chemistry (with honor), Lebanese University

Biography

Dr. El-Boubbou received his M.Sc. in Chemistry from American University of Beirut in 2005, and Ph.D. from Michigan State University (USA) in 2010. Thereafter, he worked as a postdoctoral researcher at the University of Vermont (USA). In 2013, he joined KSAU-HS as an Assistant Professor of Chemistry, and was promoted to Associate Professor in 2017. Dr. El-Boubbou authored many peer-reviewed research papers published in high-impact journals with ~ 2500 citations, several book chapters, and hold two patents. He was elected as the recipient of several awards including pre-doctoral AHA fellowship and AICCS Young Investigator Award, to name few. He also received several best paper and presentation awards in national and international conferences. Dr. El-Boubbou serves as member, referee, and reviewer for many international renowned scientific journals. His research focuses on the design of functional magnetic nanomaterials utilized for various biological, catalysis, sensing, bioremediation, and biomedical applications (i.e. detection, imaging, drug delivery, and theranostics).

Achievements

  • 2021 Arab Fund Fellowship Award, funded by Arab Fund for Economic and Social Development, Kuwait.
  • 2020 President’s Award for Excellence “Outstanding Faculty Researcher Award, KSAU-HS, Riyadh, Saudi Arabia.
  • 2017 Best Paper Award, 19th International Conference on Nano and Materials Science (ICNMS), Paris, France.
  • 2010 AICCS Young Investigator Award, Alberta Ingenuity Centre for Carbohydrate Science, Banff, Alberta, Canada.
  • 2009 Best Oral Presentation Award, 5th Midwest Carbohydrate & Glycobiology Symposium, University of Cincinnati,USA.
  • 2007 Best Oral Presentation Award, 3rd Midwest Carbohydrate & Glycobiology Symposium, Ohio State University, USA.
  • 2007 American Heart Association Pre-doctoral Fellowship Award, MSU, Michigan, USA.
  • 2006 First Year Outstanding Graduate Student, University of Toledo, Ohio, USA.
  • 2003 Honor List, B.Sc. in chemistry, Beirut, Lebanon.

Affiliations

Department of Chemistry, College of Science, University of Bahrain, Sakhir 32038, Bahrain.

Grants & Contracts Awarded

  • Arab Fund Award, Principal Investigator (PI), 2021. Hybrid Gold/Silver Iron-based Magnetic Nanoprobes for Multimodal Imaging and Photothermal Therapy.
  • PI Advances in biomedical imaging and theranostics using magnetic multifunctional nanoprobes. Project Number: RC13/204/R, KAIMRC, 2017.
  • Co-PI Developing a Nanoparticle-based detection method for MERS-CoV. Project Numbers: RC15/143/R and RC17/106/R, KAIMRC, 2018.
  • Co-PI Delivery of Plasmid DNA Incorporated Fluorescent Magnetic Nanoparticles into Isolated Single Cells: A Novel Method of Single Cell Transfection. Project Number: RC16/096/R, KAIMRC, 2018.
  • Co-PI Targeting viruses with multifunctional nanoparticles: A novel therapeutic and diagnostic approach. Project Number: RC19/121/R, KAIMRC, 2019.

Publications & Presentations

Selected Publications
  1. El-Boubbou, K.; Ximendes, E.; Teran, F. J.; Marin, R.; Artiga, A.; Ortgies, D. H.; Jaque, D. “PEGylated Opto-Magnetic Gold and Silver Sulfide Iron Oxide Nanoprobes for Synergistic Photothermal Therapy” ACS Appl. Nano Mater. 2024, 7, 12, 13959–13972. https://doi.org/10.1021/acsanm.4c02889
  2. Samman, N.; El-Boubbou, K.; Al-Muhalhil, K.; Ali, R.; Alaskar, A.; Alharbi, N.K.; Nehdi, A. “MICaFVi: A Novel Magnetic Immuno-Capture Flow Virometry Nano-Based Diagnostic Tool for Detection of Coronaviruses” Biosensors 2023, 13, 553. https://doi.org/10.3390/bios13050553
  3. Lemine, O. M.; AlGessair, S.; Madkhali, N.; Al-Najar, B.; El-Boubbou, K. “Assessing the Heat Generation and Self-Heating Mechanism of Superparamagnetic Fe3O4 Nanoparticles for Magnetic Hyperthermia Application: The Effects of Concentration, Frequency, and Magnetic Field” Nanomaterials 2023, 13(3), 453. https://doi.org/10.3390/nano13030453
  4. El-Boubbou, K.; Lemine, O. M.; Jaque, D. “Synthesis of novel hybrid mesoporous gold iron oxide nanoconstructs for enhanced catalytic reduction and remediation of toxic organic pollutants” RSC Adv. 2022, 12, 35989. https://doi.org/10.1039/d2ra05990h
  5. El-Boubbou, K.; Lemine, O. M.; Ali, R.; Huwaizi, S.; Al-Humaid, S.; AlKushi, A. “Evaluating Magnetic and Thermal Effects of Various Polymerylated Magnetic Iron Oxide Nanoparticles for Combined Chemo-Hyperthermia” New J. Chem. 2022, 46, 5489. https://doi.org/10.1039/D1NJ05791J
  6. Lemine, O. M.; Madkhali, N.; Alshammari, M.; Algessair, S.; Gismelseed, A.; El Mir, L.; Hjiri, M.; Yousif, A.; El-Boubbou, K. “Maghemite (ɣ-Fe2O3) and ɣ-Fe2O3-TiO2 Nanoparticles for Magnetic Hyperthermia Applications: Synthesis, Characterization and Heating Efficiency” Materials 2021, 14, 5691.
  7. El-Boubbou, K.; Ali, R.; Al-Zahrani, H.; Trivilegio, T.; Alanazi, A. H.; Khan, A. L.; Boudjelal, M.; AlKushi, A. “Preparation of iron oxide mesoporous magnetic microparticles as novel multidrug carriers for synergistic anticancer therapy and deep tumor penetration” Scientific Reports 2019, 9 (1), 9481.
  8. El-Boubbou, K. “Magnetic iron oxide nanoparticles as drug carriers: preparation, drug conjugation, and delivery” Nanomedicine (Lond.) 2018, 13(8), 929-952.
  9. El-Boubbou, K. “Magnetic iron oxide nanoparticles as drug carriers: clinical relevance” Nanomedicine (Lond.) 2018, 13(8), 953-971.
  10. El-Boubbou, K.; Azar, D.; Bekdash, A.; Abi-Habib, R. J. “Doxironide Magnetic Nanoparticles for Selective Drug Delivery to Human Acute Myeloid Leukemia” J. Biomed. Nanotechnol. 2017, 13, 500-512.
  11. El-Boubbou, K.; Rizwan, A.; Bahhari, H. M.; Al-Saad, K. O.; Boudjelal, M.; Kushi, A. “Magnetic fluorescent nanoformulation for intracellular drug delivery to human breast cancer, primary tumors, and tumor biopsies: Beyond targeting expectations” Bioconjugate Chem. 2016, 27, 1471-1483.
  12. El-Boubbou, K.; Zhu, D. C.; Vasileiou, C.; Borhan; B.; Prosperi, D.; Li, W.; Huang, X. “Magnetic Glyconanoparticles: A tool to detect, differentiate and unlock the glyco-codes of cancer via magnetic resonance imaging” J. Am. Chem. Soc. 2010, 132, 4490-4499.
  13. El-Boubbou, K.; Gruden, C.; Huang, X. “Magnetic Glyco-nanoparticles: A unique tool for rapid pathogen detection, decontamination and strain differentiation” J. Am. Chem. Soc. 2007, 129, 13392-13393. This publication was highlighted in the news: http://www.physorg.com/news114696140.html http://www.sciencedaily.com/releases/2007/11/071119110910.htm
PATENTS
  1. El-Boubbou, K., Ali, R., and AlKushi, A. “Iron Oxide Mesoporous Microparticle Drug Carrier” US Patent 2021, Patent no. US2021/0393798A1. https://patents.google.com/patent/US20210393798A1/en
  2. El-Boubbou, K. “Acid-stabilized iron-based metal oxide colloidal nanoparticles, and methods thereof” US Patent 2020, Patent Granted, US20170110228A1. https://patents.google.com/patent/US20170110228A1/en

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